Home Trials Current Trials

ASTN Current Trials

Insulin Resistance Intervention After Stroke Trial

E-mail Print PDF

Phase III, randomized, double-blind, placebo controlled trial. The purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke. The IRIS trial will test a new treatment strategy based on evidence linking insulin resistance to increased risk for stroke and other vascular diseases. Insulin resistance is a condition in which insulin, a normal human hormone, does not work effectively because the body is resistant to its effects. This condition can lead to diabetes and is thought to cause blood vessel disease, including stroke and heart attack, in patients with and without diabetes.

A total of 3136 participants shall be recruited. 

Last Updated ( Tuesday, 25 August 2015 13:14 )
 

AVERT: A Very Early Rehabilitation Trial

E-mail Print PDF

AVERT: A Very Early Rehabilitation Trial  

AVERT is a Phase III, international, multicentre, single blind trial comparing earlier onset and higher dose rehabilitation (mobility emphasis) with standard care. This is an investigator driven trial with NHMRC grant support. Primary outcome is death/disability at 3 months. A cost effectiveness sub-study runs beside the trial. Inclusion criteria are broad: patients > 18 years (no upper age limit), admitted <24 hours of ischemic and haemorrhagic stroke to a stroke unit. Those treated with rtPA are also eligible. Intervention is provided by a nurse/physiotherapist team.

A total of 2104 patients will be recruited to this trial.

AVERT Investigators Australia

Last Updated ( Tuesday, 25 August 2015 13:14 )
 

CIRCIT: Circit class therapy for Increasing Rehabilitation Intensity of Therapy trial

E-mail Print PDF

CIRCIT: Circit class therapy for Increasing Rehabilitation Intensity of Therapy trial

CIRCIT is a multi-centre randomized controlled trial with assessor blinding. It is a 3-armed trial which aims to examine the effectiveness of two distinct models of increasing the dose of physiotherapy provided to people during sub-acute rehabilitation. Usual care physiotherapy (provided over 5 day week) is the control group and will be compared to usual care therapy provided over 7 days a week (7-day therapy) and group circuit therapy provided over 5-days a week (circuit class therapy). The group nature of circuit class therapy has been proven able to deliver an approximate four-fold increase in therapy dose per working day. The primary outcome is walking capacity (6 minute walk test) at 4 weeks. The secondary aim is to examine the relative cost-effectiveness of the dofferent models of care.

We are currently recruiting from three rehabilitation centres in South Australia, one in Western Australia amd a fifth site in Victoria soon to commence recruitment. Our target sample is 282.

Last Updated ( Tuesday, 25 August 2015 13:14 )
 

EXTEND: Extending the time for Thrombolysis in Emergency Neurological Deficits

E-mail Print PDF

Phase III, randomised, multicentre, double blinded, placebo controlled trial (2 arm with 1:1 randomisation) within a larger cohort study of ischaemic stroke patients. Patients randomised to treatment will be stratified for time of randomisation after stroke to within <6 hours and 6-9 hours. The primary hypothesis being tested in this trial is that ischaemic stroke patients selected with significant penumbral mismatch (measured by MRI criteria) at 3 - 9 hours post onset of stroke will have improved clinical outcomes when given intravenous tissue plasminogen activator (tPA) compared to placebo.

A total of 400 participants shall be recruited.    

Extend Investigators in China

Last Updated ( Tuesday, 25 August 2015 13:14 )
 
Page 3 of 3


ASTN Latest news

Top Views